The problem of constructing of the Sobol ev orthogonal polynomials sαr,n(x) generated by Char li er polynomialssαn(x) is considered. It is shown that the system of polynomials sαr,n(x) generated by Charlier polynomialsis complete in the space Wrl, consisted of the discrete functions, given on the grid Ω = {0, 1, . . .}. Wrlρisa H ilb ert space with the inner product hf, gi. An explicit formula in the form of sαr,k+r(x) =kPl=0brlx[l+r],where xm]= x(x −1) . . . (x − m + 1), is found.